α–Glucosidase Inhibitory Activities of Crude Extract from Mitragyna speciosa Korth. Leaves

Abstract

Mitragyna speciosa Korth., commonly known as Kratom, is a herbaceous plant found in southern regions and is known for its high content of alkaloids, mainly mitragynine. To study the potential of crude extract from Mitragyna speciosa Korth. leaves on a–glucosidase inhibitory activities is the aim of this study. The leaves were extracted using dichloromethane, ethyl acetate, and methanol as the solvents with the maceration technique. The extraction results showed the crude yields of chloroform, ethyl acetate, and methanol were 2.37, 0.95 and 8.18%, respectively. The  a–glucosidase inhibitory activities of the crude extracts found that the crude dichloromethane, ethyl acetate and methanol extracts had inhibitory activities with IC₅₀ values of 103.71, 78.33 and 66.72 µg/mL, respectively.  The crude extract of methanol is close to the IC₅₀ value of the standard substance acarbose, which is 61.62 µg/mL. Therefore, the research can be concluded that the crude methanol extracts from Mitragyna speciosa Korth. leaves have the potential to be further developed as a diabetes drug.