Bioactive Compounds in Mushrooms and the Benefits of Using Artificial Light for Cultivation
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Abstract
Mushrooms are living organisms that produce a variety of bioactive compounds such as polysaccharides, proteins, phenolics and terpenes, which have biological effects, for example, enhancing immunity, reducing blood sugar, inhibiting cholesterol synthesis, and inhibiting cancer cell growth through cell apoptosis, cell cycle arrest, suppression of cell migration, and more. Due to these properties, mushrooms are considered to be a superfood for health, and their bioactive substances are often used as ingredients in food and cosmetic products. Therefore, in recent years, numerous studies have been conducted to stimulate growth and the production of bioactive substances in mushrooms, intended for supply to industries. This review aims to explore the bioactive effects found in mushrooms, as well as the appropriate wave length of artificial light to stimulate growth and the production of bioactive substances in mushrooms.
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References
Abdellatef, A. A., Meselhy, M. R., El-Askary, H. I., El-mekkawy, S., Hayakawa, Y. (2022). Anti-metastatic function of triterpene phytochemicals from guggul by targeting tumor-intrinsic NF-kB activation in triple-negative breast cancer cells. Phytomedicine Plus, 2(4), 100345. doi: 10.1016/j.phyplu.2022.100345
Afiati, F., Firza, S. F., Kusmiati, Aliya, L. S. (2019). The effectiveness β-glucan of shiitake mushrooms and Saccharomyces cerevisiae as antidiabetic and antioxidant in mice Sprague Dawley induced alloxan. AIP Conference Proceedings, 2120(1), 070006. doi: 10.1063/1.5115723
Ahmad, M. F. (2019). Ganoderma lucidum: A Macro Fungus with Phytochemicals and Their Pharmacological Properties. Plant and Human Health, Volume 2: Phytochemistry and Molecular Aspects, 491-515. doi: 10.1007/978-3-030-03344-6_21
Bergendiova, K., Tibenska, E., Majtan, J. (2011). Pleuran (β-glucan from Pleurotus ostreatus) supplementation, cellular immune response and respiratory tract infections in athletes. European Journal of Applied Physiology, 111(9), 2033-2040. doi: 10.1007/s00421-011-1837-z
Bishop, K. S., Kao, C. H. J., Xu, Y., Glucina, M. P., Paterson, R. R. M., Ferguson, L. R. (2015). From 2000 years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry, 114, 56-65. doi: 10.1016/j.phytochem.2015.02.015
Carrasco-González, J. A., Serna-Saldívar, S. O., Gutiérrez-Uribe, J. A. (2017). Nutritional composition and nutraceutical properties of the Pleurotus fruiting bodies: Potential use as food ingredient. Journal of Food Composition and Analysis, 58, 69-81. doi: 10.1016/j.jfca.2017.01.016
Chiang, S. S., Liang, Z. C., Wang, Y. C., Liang, C. H. (2017). Effect of light-emitting diodes on the production of cordycepin, mannitol and adenosine in solid-state fermented rice by Cordyceps militaris. Journal of Food Composition and Analysis, 60, 51-56. doi:10.1016/j.jfca.2017.03.007
Chien, C. C., Tsai, M. L., Chen, C. C., Chang, S. J., Tseng, C. H. (2008). Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms. Mycopathologia, 166(2), 117-120. doi: 10.1007/s11046-008-9128-x
Chowdhury, M. M. H., Kubra, K., Ahmed, S. R. (2015). Screening of antimicrobial, antioxidant properties and bioactive compounds of some edible mushrooms cultivated in Bangladesh. Annals of Clinical Microbiology and Antimicrobials, 14(1), 8. doi: 10.1186/s12941-015-0067-3
Du, F., Zou, Y., Hu, Q., Zhang, H., Ye, D. (2020). Comparative transcriptomic analysis reveals molecular processes involved in pileus morphogenesis in Pleurotus eryngii under different light conditions. Genomics, 112(2), 1707-1715. doi: 10.1016/j.ygeno.2019.09.014
Fatmawati, S., Shimizu, K., Kondo, R. (2011). Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum. Phytomedicine, 18(12), 1053-1055. doi: 10.1016/j.phymed.2011.03.011
Feng, Y., Xu, H., Sun, Y., Xia, R., Hou, Z., Li, Y., Wang, Y., Pan, S., Li, L., Zhao, C., Ren H., Xin, G. (2023). Effect of light on quality of preharvest and postharvest edible mushrooms and its action mechanism: A review. Trends in Food Science & Technology, 139, 104119. doi: 10.1016/j.tifs.2023.104119
Fisher, M., Yang, L. X. (2002). Anticancer effects and mechanisms of polysaccharide-K (PSK): Implications of cancer immunotherapy. Anticancer Research, 22(3), 1737-1754.
Ghorai, S., Banik, S. P., Verma, D., Chowdhury, S., Mukherjee, S., Khowala, S. (2009). Fungal biotechnology in food and feed processing. Food Research International, 42(5), 577-587. doi: 10.1016/j.foodres.2009.02.019
Handa, N., Yamada, T., Tanaka, R. (2010). An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus. Phytochemistry, 71(14), 1774-1779. doi: 10.1016/j.phytochem.2010.07.005
He, M., Su, D., Liu, Q., Gao, W., Kang, Y. (2017). Mushroom lectin overcomes hepatitis B virus tolerance via TLR6 signaling. Scientific Reports, 7(1). doi: 10.1038/s41598-017-06261-5
Hsin, I. L., Ou, C. C., Wu, M. F., Jan, M.-S., Hsiao, Y. M., Lin, C.-H., Ko, J. L. (2015). GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells. Molecular Pharmaceutics, 12(5), 1534-1543. doi: 10.1021/mp500840z
Hyun, J.-E., & Lee, S.-Y. (2020). Blue light-emitting diodes as eco-friendly non-thermal technology in food preservation. Trends in Food Science and Technology, 105, 284-295. doi: 10.1016/j.tifs.2020.09.008
Jang, M. J., Lee, Y. H., Ju, Y. C., Kim, S. M., & Koo, H. M. (2013). Effect of Color of Light Emitting Diode on Development of Fruit Body in Hypsizygus marmoreus. Mycobiology, 41(1), 63-66. doi: 10.5941/MYCO.2013.41.1.63
Jedinak, A., Dudhgaonkar, S., Jiang, J., Sandusky, G., & Sliva, D. (2010). Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice. International Journal of Molecular Medicine, 26(5), 643-650. doi: 10.3892/ijmm_00000509
Kim, D. Y., Jang, M.-J., Park, Y.-J., & Kim, J. Y. (2021). Transcriptome Analysis Identified Candidate Genes Involved in Fruit Body Development under Blue Light in Lentinula edodes. Applied Sciences, 11(15). doi: 10.3390/app11156997
Kim, J. W., Kim, H. I., Kim, J. H., Kwon, O. C., Son, E. S., Lee, C. S., Park, Y. J. (2016). Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. International Journal of Molecular Sciences, 17(11). doi: 10.3390/ijms17111798
Kojima, M., Kimura, N., & Miura, R. (2015). Regulation of primary metabolic pathways in oyster mushroom mycelia induced by blue light stimulation: accumulation of shikimic acid. Scientific Report, 5, 8630. doi: 10.1038/srep08630
Kour, H., Kour, D., Kour, S., Singh, S., Hashmi, S. A. J., Yadav, A. N., Kumar, K., Sharma, Y., P. Ahluwalia, A. S. (2022). Bioactive compounds from mushrooms: Emerging bioresources of food and nutraceuticals. Food Bioscience, 50, 102124. doi: 10.1016/j.fbio.2022.102124
Kozarski, M., Klaus, A., Jakovljevic, D., Todorovic, N., Vunduk, J., Petrović, P., Niksic, M., Vrvic, M.,M., Griensven, V., L. (2015). Antioxidants of Edible Mushrooms. Molecules, 20(10), 19489-19525. doi: 10.3390/molecules201019489
Kumaran, S., Pandurangan, A. K., Shenbhagaraman, R., Esa, N. M. (2017). Isolation and characterization of lectin from the artist’s conk medicinal mushroom, Ganoderma applanatum (Agaricomycetes), and evaluation of its antiproliferative activity in HT-29 colon cancer cells. International Journal of Medicinal Mushrooms, 19(8), 675-684. doi:10.1615/IntJMedMushrooms.2017021274
Li, Y. R., Liu, Q. H., Wang, H. X., Ng, T. B. (2008). A novel lectin with potent antitumor, mitogenic and HIV-1 reverse transcriptase inhibitory activities from the edible mushroom Pleurotus citrinopileatus. Biochimica et Biophysica Acta, 1780(1), 51-57. doi: 10.1016/j.bbagen.2007.09.004
Lin, S., Ching, L. T., Chen, J., Cheung, P. C. K. (2015). Antioxidant and anti-angiogenic effects of mushroom phenolics-rich fractions. Journal of Functional Foods, 17, 802-815. doi: 10.1016/j.jff.2015.06.015
Ma, G., Yang, W., Zhao, L., Pei, F., Fang, D., Hu, Q. (2018). A critical review on the health promoting effects of mushrooms nutraceuticals. Food Science and Human Wellness, 7(2), 125-133. doi: 10.1016/j.fshw.2018.05.002
Moro, C., Palacios, I., Lozano, M., D’Arrigo, M., Guillamón, E., Villares, A., Martinez, J., A., García-Lafuente, A. (2012). Anti-inflammatory activity of methanolic extracts from edible mushrooms in LPS activated RAW 264.7 macrophages. Food Chemistry, 130(2), 350-355. doi: 10.1016/j.foodchem.2011.07.049
Phan, C.-W., Tan, E. Y.-Y., Sabaratnam, V. (2019). Bioactive Molecules in Edible and Medicinal Mushrooms for Human Wellness., Bioactive Molecules in Food (pp. 1597-1620). doi: 10.1007/978-3-319-78030-6_83
Ren, D., Wang, N., Guo, J., Yuan, L., Yang, X. (2016). Chemical characterization of Pleurotus eryngii polysaccharide and its tumor-inhibitory effects against human hepatoblastoma HepG-2 cells. Carbohydrate Polymers, 138, 123-133. doi: 10.1016/j.carbpol.2015.11.051
Ren, L., Perera, C., Hemar, Y. (2012). Antitumor activity of mushroom polysaccharides: a review. Food & Function, 3(11), 1118-1130. doi: 10.1039/c2fo10279j
Ríos, J.-L. (2010). Effects of triterpenes on the immune system. Journal of Ethnopharmacology, 128(1), 1-14. doi: 10.1016/j.jep.2009.12.045
Ruan, J., Li, H., Lu, M., Hao, M., Sun, F., Yu, H., Zhang, Y., Wang, T. (2023). Bioactive triterpenes of jujube in the prevention of colorectal cancer and their molecular mechanism research. Phytomedicine, 110, 154639. doi: 10.1016/j.phymed.2022.154639
Saltarelli, R., Palma, F., Gioacchini, A. M., Calcabrini, C., Mancini, U., De Bellis, R., Stocchi, V., Potenza, L. (2019). Phytochemical composition, antioxidant and antiproliferative activities and effects on nuclear DNA of ethanolic extract from an Italian mycelial isolate of Ganoderma lucidum. Journal of Ethnopharmacology, 231, 464-473. doi: 0.1016/j.jep.2018.11.041
Shi, M., Zhang, Z., Yang, Y. (2013). Antioxidant and immunoregulatory activity of Ganoderma lucidum polysaccharide (GLP). Carbohydrate Polymers, 95(1), 200-206. doi: 10.1016/j.carbpol.2013.02.081
Srikram, A., Supapvanich, S. (2016). Proximate compositions and bioactive compounds of edible wild and cultivated mushrooms from Northeast Thailand. Agriculture and Natural Resources, 50(6), 432-436. doi: 10.1016/j.anres.2016.08.001
Taofiq, O., Heleno, S. A., Calhelha, R. C., Alves, M. J., Barros, L., González-Paramás, A. M., Barreito, M. F., Ferreira, I. (2017). The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits. Food and Chemical Toxicology, 108(Pt A), 139-147. doi: 10.1016/j.fct.2017.07.051
Tian, L., Wang, X., Li, X., Liu, B., Zhang, W., Cao, J., Ning A., Huang M., Zhong, M. (2016). In vitro antitumor activity of Latcripin-15 regulator of chromosome condensation 1 domain protein. Oncology Letters, 12(5), 3153-3160. doi: 10.3892/ol.2016.5106
Tong, A., Wu, W., Chen, Z., Wen, J., Jia, R., Liu, B., Cao Zhao, C. (2023). Modulation of gut microbiota and lipid metabolism in rats fed high-fat diets by Ganoderma lucidum triterpenoids. Current Research in Food Science, 6, 100427. doi:10.1016/j.crfs.2022.100427
Wang, H., Tong, X., Tian, F., Jia, C., Li, C., Li, Y. (2020). Transcriptomic profiling sheds light on the blue-light and red-light response of oyster mushroom (Pleurotus ostreatus). AMB Express, 10(1), 10. doi: 10.1186/s13568-020-0951-x
Wang, H. X., Ng, T. B. (2006a). A laccase from the medicinal mushroom Ganoderma lucidum. Applied Microbiology and Biotechnology, 72(3), 508-513. doi: 10.1007/s00253-006-0314-9
Wang, H. X., Ng, T. B. (2006b). Purification of a laccase from fruiting bodies of the mushroom Pleurotus eryngii. Applied Microbiology and Biotechnology, 69(5), 521-525. doi: 10.1007/s00253-005-0086-7
Wang, J., Cao, B., Zhao, H., Feng, J. (2017). Emerging Roles of Ganoderma lucidum in Anti-Aging. Aging Disorder, 8(6), 691-707. doi: 10.14336/AD.2017.0410
Wang, J., Wan, X., Gao, Y., Zhong, M., Sha, L., Liu, B., Zhang, W., Tian, Li, Ruan, W., Cao, S., Huang, M. (2016). Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells. Oncology Report, 36(1), 441-447. doi: 10.3892/or.2016.4830
Wang, S., Bao, L., Zhao, F., Wang, Q., Li, S., Ren, J., Li, L., Wen, H., Guo, L. Liu, H. (2013). Isolation, Identification, and Bioactivity of Monoterpenoids and Sesquiterpenoids from the Mycelia of Edible Mushroom Pleurotus cornucopiae. Journal of Agricultural and Food Chemistry, 61(21), 5122-5129. doi: 10.1021/jf401612t
Wang, W., Gou, X., Xue, H., Liu, K. (2019). Ganoderan (GDN) Regulates The Growth, Motility And Apoptosis of Non-Small Cell Lung Cancer Cells through ERK Signaling Pathway In Vitro and In Vivo. Onco Targets Therapy, 12, 8821-8832. doi: 10.2147/OTT.S221161
Wang, Y. Q., Bao, L., Yang, X. L., Dai, H. Q., Guo, H., Yao, X. S., Zhang, L. X., Liu, H. W. (2012). Four New Cuparene-Type Sesquiterpenes from Flammulina velutipes. Helvetica Chimica Acta, 95(2), 261-267. doi: 10.1002/hlca.201100289
Wong, J. H., Wang, H. X., Ng, T. B. (2008). Marmorin, a new ribosome inactivating protein with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from the mushroom Hypsizigus marmoreus. Applied Microbiology and Biotechnology, 81(4), 669-674. doi: 10.1007/s00253-008-1639-3
Wu, J. Y., Chen, C. H., Chang, W. H., Chung, K. T., Liu, Y. W., Lu, F. J., Chen, C. H. (2011). Anti-Cancer Effects of Protein Extracts from Calvatia lilacina, Pleurotus ostreatus and Volvariella volvacea. Evidence-Based Complementary and Alternative Medicine, 2011, 982368. doi: 10.1093/ecam/neq057
Wu, J. Y., Chen, H. B., Chen, M. J., Kan, S. C., Shieh, C. J., Liu, Y. C. (2013). Quantitative analysis of LED effects on edible mushroom Pleurotus eryngii in solid and submerged cultures. Journal of Chemical Technology
& Biotechnology, 88(10), 1841-1846. doi: 10.1002/jctb.4038
Xiao, C., Wu, Q., Zhang, J., Xie, Y., Cai, W., Tan, J. (2017). Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice. Journal of Ethnopharmacology, 196, 47-57. doi: 10.1016/j.jep.2016.11.044
Xie, C., Gong, W., Zhu, Z., Yan, L., Hu, Z., Peng, Y. (2018). Comparative transcriptomics of Pleurotus eryngii reveals blue-light regulation of carbohydrate-active enzymes (CAZymes) expression at primordium differentiated into fruiting body stage. Genomics, 110(3), 201-209. doi : 10.1016/j.ygeno.2017.09.012
Xu, H., Kong, Y. Y., Chen, X., Guo, M. Y., Bai, X. H., Lu, Y. J., Li, W., Zhou, X. W. (2016). Recombinant FIP-gat, a Fungal Immunomodulatory Protein from Ganoderma atrum, Induces Growth Inhibition and Cell Death in Breast Cancer Cells. Journal of Agricultural and Food Chemistry, 64(13), 2690-2698. doi: 10.1021/acs.jafc.6b00539
Xu, X., Yan, H., Chen, J., Zhang, X. (2011). Bioactive proteins from mushrooms. Biotechnology Advances, 29(6), 667-674. doi: 10.1016/j.bio
techadv.2011.05.003
Yang, B. K., Kim, D. H., Jeong, S. C., Das, S., Choi, Y. S., Shin, J. S., Lee, S., C., Song, C. H. (2002). Hypoglycemic effect of a lentinus edodes exo-polymer producedfrom a submerged mycelial culture. Bioscience, Biotechnology and Biochemistry, 66(5), 937-942. doi: 10.1271/bbb.66.937
Yelithao, K., Surayot, U., Lee, C., Palanisamy, S., Prabhu, N. M., Lee, J., You, S. (2019). Studies on structural properties and immune-enhancing activities of glycomannans from Schizophyllum commune. Carbohydrate Polymers, 218, 37-45. doi: 10.1016/j.carbpol.2019.04.057
Yu, Y., Shen, M., Song, Q., Xie, J. (2018). Biological activities and pharmaceutical applications of polysaccharide from natural resources: A review. Carbohydrate Polymers, 183, 91-101. doi: 10.1016/j.carbpol.2017.12.009
Zhang, L., Zhang, X., Zhou, Q., Zhang, P., Zhang, M., Li, X. (2001). Triple Helix of β-D-Glucan from Lentinus Edodes in 0.5 M NaCl Aqueous Solution Characterized by Light Scattering. Polymer Journal, 33(4), 317-321. doi: 10.1295/polymj.33.317
Zhang, R. Y., Zhang, G. Q., Hu, D. D., Wang, H. X., Ng, T. B. (2010). A Novel Ribonuclease with Antiproliferative Activity from Fresh Fruiting Bodies of the Edible Mushroom Lyophyllum shimeiji. Biochemical Genetics, 48(7), 658-668. doi: 10.1007/s10528-010-9347-y
Zhang, Y., Mei, H., Shan, W., Shi, L., Chang, X., Zhu, Y., Chen, F., Han, X. (2016). Lentinan protects pancreatic β cells from STZ-induced damage. Journal of Cellular and Molecular Medicine, 20(10), 1803-1812. doi: 10.1111/jcmm.12865
Zhang, X., Bian, Z., Yuan, X., Chen, X., Lu, C. (2020). A review on the effects of light-emitting diode (LED) light on the nutrients of sprouts and microgreens. Trends in Food Science & Technology, 99, 203-216. doi: 10.1016/j.tifs.2020.02.031