Effects of Long-term Treatment of Butea superba on Sperm Motility

Authors

  • Chainarong Tocharus Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
  • Rattima Jeenapongsa Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
  • Thanasak Teakthong Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
  • Yuthana Smitasiri Faculty of Science, Mae Fah Luang University, Chiangrai 57100, Thailand.

Keywords:

Butea superba, Kwaao Khruea, sperm motility, sperm count

Abstract

Butea superba has been used to enhance sexual performance in men with unknown long-term effects on spermatozoa.  This study aimed to investigate effects of chronic treatment of B. superba on sperm motility and concentration in rats and mice in correlation with testicular damage.  Adult male rats and mice were orally administered distilled water or B. superba alcoholic extract (0.01, 0.1 or 1.0 mg/kg BW/day) for 6 months.  At the end of the treatment the animals were sacrificed and the spermatozoa recovered from the distal cauda epididymis were analyzed for sperm concentration and motility in vitro.  The testes were processed for histological examination.  The results show that long-term treatment with B. superba extract significantly increased the sperm concentration and delayed the decreased motility with time.  None of signs of sperm anomalies and testicular damages were observed.  This suggests that chronic use of B. superba increases the number of sperm, prolongs sperm motility in vitro while produces no changes on sperm morphology.  Therefore, chronic use of B. superba alcoholic extract may be useful in fertilization.

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Published

2005-06-02

Issue

Vol. 13 No. 2 (2005): May-August 2005

Section

Research Articles

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Copyright (c) 2005 Naresuan University Journal: Science and Technology

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