Efficacy and Safety of Curcuminoids Loaded Solid Lipid Nanoparticles Facial Cream as an Anti-aging Agent

Abstract

Dried turmeric powder has long been incorporated as an active ingredient in various cosmetic products. Recently, the antioxidant properties of curcuminoids have gained enormous attention as an anti-aging agent. The aims of this study were to (1) evaluate the effect of curcuminoids loaded solid lipid nanoparticles (SLN) facial cream as an anti-aging agent in healthy volunteers, and (2) test the safety of this product. This study was a prospective, half-face, randomization of face, cream base control trial. Thirty-three healthy volunteers with noticeable facial wrinkles participated in this study. The participants applied curcuminoids loaded SLN cream and cream base on the assigned side of their faces before bed for eight weeks. Skin wrinkles, hydration, melanin content, biological elasticity, and viscoelasticity were main outcomes measured. Skin irritation was indicated by transepidermal water loss index, skin pH, and physician's observations. The results indicated that, from week three onward, all measures of efficacy of the treatment side were significantly better than the control side. When compared with their baselines, all efficacy measures were significantly improved by two weeks. In addition, no sign of skin irritation was observed. In conclusion, curcuminoids loaded SLN cream was effective as an anti-aging preparation with acceptable safety.