องค์ประกอบทางเคมีและฤทธิ์ต้านการกลายพันธุ์ของสารสกัดสมุนไพรฮว่านง๊อก

Phytochemical contents and antimutagenicity of Hoan Ngoc extracts

Abstract

Hoan Ngoc (Pseuderatherum platiferum) is the medicinal plant from Vietnam. It is claimed in several pharmacological properties. However, the scientific data to support their properties still limit. This study aimed to investigate the antimutagenic activity of water and ethanolic extracts from Hoan Ngoc leaves. The results showed that both extracts possessed very potent antimutagenic activity against sodium azide (NaN3) in strains TA98 and TA100 of Salmonella typhimurium. In TA 98, the antimutagenicity of ethanolic extract was significantly higher than that of water extract with IC50 8.53±0.06 μg/plate and 15.11±0.05 μg/plate, respectively. The significant antimutagenicity of ethanolic extract also were obtained to TA100 with IC5010.49±0.03 μg/plate while IC50 of water extract was 17.99±0.32 μg/plate. In according to the antimutagenic effect, the amount polyphenolic and flavonoid in ethanolic extract is significantly higher than that of water extract. The polyphenol contents of ethanolic extract and water extract was 9.2±0.61 mgGAE/g fresh weight and 1.1±0.06 mgGAE/g fresh weight, respectively. The flavonoid contents of ethanolic extract and water extract was 2.3±0.37 mgQE/g fresh weight and 0.5±0.03 mgQE/g fresh weight, respectively. The large amount of polyphenol and flavonoid contents in ethanolic extract may cause its strong antimutagenic activity. Therefore, Hoan Ngoc extracts have the antimutagenic activity which are interesting to be further studied on their anticancer activity and the other biological activities.