เซลล์บุผนังหลอดเลือดในโรคเบาหวาน

Vascular endothelium in diabetes mellitus

Abstract

The endothelium plays a key role in the regulation of numerous vascular functions, including vascular tone, vascular inflammation,
and coagulation. Dysfunction of the vascular endothelium is thought to be an early event in the beginning of atherosclerosis and
important in the vascular complications in diabetes mellitus. There are many mechanisms that contribute to endothelial dysfunction in
diabetes include the activation of protein kinase C (PKC) pathways, increased polyol pathway flux, accelerated non-enzymatic
formation of advanced glycation end products (AGEs), and increased oxidant stress. Therefore, this article summarizes the important
mechanisms of endothelial dysfunction in diabetes, which lead to the therapeutic application or drug development for the treatment or prevention of vascular complications that may occur in diabetic patients.