Anti-androgenic activity of furanodiene isolated from Curcuma aeruginosa Roxb. extract

Jukkarin Srivilai; Nantaka Khorana; Neti Waranuch; Kornkano Ingkaninan

Authors

Jukkarin Srivilai Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Science and Center of Excellence forInnovation in Chemistry, Naresuan University, Phitsanulok, Thailand
Nantaka Khorana Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Science and Center of Excellence forInnovation in Chemistry, Naresuan University, Phitsanulok, Thailand
Neti Waranuch Department of Pharmaceutical Technology, Faculty of Pharmaceutical Science and Center of Excellence for Innovation in Chemistry,Naresuan University, Phitsanulok, Thailand
Kornkano Ingkaninan DepartmentofPharmaceuticalChemistry and Pharmacognosy, Faculty ofPharmaceuticalScience and CenterofExcellence forInnovation in Chemistry, Naresuan University, Phitsanulok, Thailand

Keywords:

anti-androgen, 5-alpha reductase inhibitor, Curcuma aeruginosa Roxb., furanodiene, sesquiterpenes

Abstract

Human 5-alpha reductase enzyme is involved in the development of benign prostatic hyperplasia, androgenic alopecia, hirsutism,
prostate cancer, and acne skin. The inhibitors of this enzyme can be used for the treatment of these diseases. From our previous vitro
and in vivo studies, the rhizome of a Thai medicinal plant, Curcuma aeruginosa Roxb. (Zingiberaceae) showed significant antiandrogenic effects. In this study, we aim to search for the 5-alpha reductase inhibitors from the plant. The major constituent in this
plant, furanodiene was isolated and identified using chromatographic and spectroscopic techniques. At the concentration of 1 mg/ml,
furanodiene showed 40% inhibition effect on 5-alpha reductase. This sesquiterpenenoid compound can be a potential lead for the
development of anti-androgenic drugs.