Role of Nck in T Cell Receptor Activation

Ichaya Yiemwattana; Jatuporn Ngoenkam; Sutatip Pongcharoen

Authors

Ichaya Yiemwattana Department of Preventive Dentistry, Faculty of Dentistry
Jatuporn Ngoenkam Department of Microbiology and Parasitology, Faculty of Medical Science
Sutatip Pongcharoen Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

Keywords:

Nck, adaptor protein, TCR activation, T cells

Abstract

The non-catalytic region of tyrosine kinase (Nck) is an important regulator of the cytoskeletal reorganization and of the formation of the immune synapse between T cells and antigen presenting cells (APCs). Nck acts as a link between the TCR:CD3 complex and signaling molecules that mediate cytoskeleton rearrangement and T cell activation. The intracellular T cell signaling both in an immunoreceptor tyrosine-based activation motif (ITAM)-requiring mechanism and in a non-ITAM-requiring mechanism may be regulated by Nck. Therefore, this review attempts to summarise the critical role of Nck in T cell receptor activation. The subsequent applications may contribute to the usage of Nck as a target for pharmacological modulation of the immunopathologic conditions.