Acute respiratory distress syndrome (ARDS): An evidence-based management

Phuttaphong Nipatta

doi:10.14456/nujst.2019.19

Authors

Phuttaphong Nipatta Department of medicine, Naresuan University, Phitsanulok, Thailand, 65000

DOI:

https://doi.org/10.14456/nujst.2019.19

Keywords:

acute respiratory distress syndrome, pulmonary edema, treatment

Abstract

Acute respiratory distress syndrome (ARDS) is a common acute respiratory failure problem in critically ill patients, with mortality rates of around 40.0% and causing long-term morbidity in survivors. ARDS has been defined as Berlin-Definition and may modify in resource-constrained settings. Various etiologies can induce lung inflammation and leading to the diffuse pulmonary edema that defines ARDS. The main treatment consists of specific correct lung injury etiology and support in critical illness that must be undertaken simultaneously. Several supportive strategies: lung-protective ventilation, prone positioning and neuromuscular blocking agent in order to facilitate mechanical ventilation, show a significant reduction in mortality. ARDS management in present day, shifting toward prevention and early treatment, is likely to reduce the incidence and burden of this syndrome.

References

Ashbaugh, D. G., Bigelow, D. B., Petty, T. L., & Levine, B. E. (1967). Acute respiratory distress in adults. The Lancet, 2, 319-323.

Ranieri, V. M., Rubenfeld, G. D., Thompson, B. T., Ferguson, N. D., Caldwell, E., Fan, E., … Pesenti, A. (2012). Acute respiratory distress syndrome: the Berlin definition. The Journal of the American Medical Association, 307(23), 2526–2533.

Brun-Buisson, C., Minelli, C., Bertolini, G., Brazzi, L., Pimentel, J., Lewandowski, K., … Lemaire, F. (2004). Epidemiology and outcome of acute lung injury in European intensive care units. Results from the ALIVE study. Intensive Care Medicine, 30(1), 51-61.

Bellani, G., Laffey, J. G., Pham, T., Fan, E., Brochard, L., Esteban, A., … Pesenti, A. (2016). Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. The Journal of the American Medical Association, 315(8), 788–800.

Elisabeth, D. R., Willy, K., Twagirumugabe, T., Mueller, A., Banner-Goodspeed, V. M., Officer, L., … Fowler, R. A . (2016). Hospital Incidence and Outcomes of the Acute Respiratory Distress Syndrome Using the Kigali Modification of the Berlin Definition. American Journal of Respiratory and Critical Care Medicine, 193(1), 52-59.

Biehl, M., Kashyap, R., Ahmed, A., Reriani, M., Ofoma, U., Wilson, G., … Gajic, O. (2015). Six-month quality-of-life and functional status of acute respiratory distress syndrome survivors compared with patients at risk: a population-based study. Critical Care, 19, 356.

Bienvenu, O. J., Colantuoni, E., Pedro, A., Shanholtz, C., Dennison-Himmelfarb C.R., Pronovost, P. J., & Needham, D. (2015). Co-occurrence of and remission from general anxiety, depression, and posttraumatic stress disorder symptoms after acute lung injury: a 2-year longitudinal study. Critical Care Medicine, 43(3), 642–653.

Sensen B., Braune S., Heer G., Bein T., & Kluge, S. (2017). Life after ARDS. Med Klin Intensivmed Notfmed, 112(7), 605–611.

Hemang, Y., Taylor, T., & Gajic, O. (2017). FIFTY YEARS OF RESEARCH IN ARDS: Is Acute Respiratory Distress Syndrome a Preventable Disease. American Journal of Respiratory and Critical Care Medicine, 195(6), 725-736.

Gajic, O., Dabbagh, O., Park, P. K., Adesanya, A., Chang, S. Y., Hou, P., … Malinchoc, M. (2011). Lung Injury Prevention Study Investigators (USCIITG-LIPS). Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. American Journal of Respiratory and Critical Care Medicine, 462–470.

Guangxi, L., Michael, M., Rodrigo, C., Chakradhar, V., Daryl, J. K., Steve, G. P., Rolf, D. H., & Gajic, O. (2011). Eight-Year Trend of Acute Respiratory Distress Syndrome: A Population-based Study in Olmsted County, Minnesota. American Journal of Respiratory and Critical Care Medicine, 183, 59–66.

Frat, J. P., Thille, A. W., Mercat, A., Girault, C., Ragot, S., Perbet, S., … Robert, R. (2015). High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. The New England journal of medicine, 372(23), 2185–2196.

Patel, B. K., Wolfe, K. S., Pohlman, A. S., Hall, J. B., & Kress, J. P. (2016). Effect of noninvasive ventilation delivered by helmet vs face mask on the rate of endotracheal intubation in patients with acute respiratory distress syndrome: a randomized clinical trial. The Journal of the American Medical Association, 315(22), 2435–2441.

Gattinoni, L., Marini, J. J., Pesenti, A., Quintel, M., Mancebo, J., & Brochard, L. (2016). The “baby lung” became an adult. Intensive Care Medicine, 42(5), 663–673.

Henderson, W. R., Chen, L., Amato, M. B. P., & Brochard, L. J. (2017). FIFTY YEARS OF RESEARCH IN ARDS: Respiratory Mechanics in Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine, 196(7), 822-833.

Curley, G. F., Laffey, J. G., Zhang, H., & Slutsky A. S. (2016). Biotrauma and ventilator induced lung injury: clinical implications. Chest Journal, 150(5),1109–1117

Brower, R. G., Matthay, M. A., Morris, A., Schoenfeld, D., Thompson, B. T., & Wheeler, A. (2000). Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The New England journal of medicine, 342(18), 1301-1308.

Retamal, J., Libuy, J., Jimenez, M., Delgado, M., Besa, C., Bugedo, G., & Bruhn, A. (2013). Preliminary study of ventilation with 4 ml/kg tidal volume in acute respiratory distress syndrome: feasibility and effects on cyclic recruitment–derecruitment and hyperinflation. Critical Care, 17, R16.

Fanelli, V., Ranieri, M. V., Mancebo, J., Moerer, O., Quintel, M., Morley, S., … Combes, A. (2016). Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome. Critical Care, 20, 36.

Amato, M. B., Meade, M. O., Slutsky, A. S., Brochard, L., Costa, E. L., Schoenfeld, D. A., … Brower, R. G. (2015), Driving pressure and survival in the acute respiratory distress syndrome. The New England journal of medicine, 372(8), 747–755.

Talmor, D., Sarge, T., Malhotra, A., O'Donnell, C. R., Ritz, R., Lisbon, A., … Loring, S. H. (2008). Mechanical ventilation guided by esophageal pressure in acute lung injury. The New England journal of medicine, 359(20), 2095–2104.

Suzumura, E. A., Amato, M. B., & Cavalcanti, A. B. (2016). Understanding recruitment maneuvers. Intensive Care Medicine, 42(5), 908-911.

Goligher, E. C., Kavanagh, B. P., Rubenfeld, G. D., Adhikari, N. K., Pinto, R., Fan, E., … Ferguson, N. D. (2014). Oxygenation response to positive end-expiratory pressure predicts mortality in acute respiratory distress syndrome. A secondary analysis of the LOVS and ExPress trials. American Journal of Respiratory and Critical Care Medicine, 190(1),70-76.

Kasenda, B., Sauerbrei, W., Royston, P., Mercat, A., Slutsky, A. S., Cook, D., … Briel, M. (2016). Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS. British Medical Journal Open, 6(9), e011148.

Cavalcanti, Suzumura, Amato, M. B., Laranjeira, L. N., Paisani, D. M., Damiani, L. P., … Berwanger, O. (2017). Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial. The Journal of the American Medical Association, 318(14), 1335-1345.

Gattinoni, L., Caironi, P., Cressoni, M., Chiumello, D., Marco, R. V., Michael, Q., … Guillermo, B. (2006). Lung recruitment in patients with the acute respiratory distress syndrome. The New England journal of medicine, 1775-1786.

Salvatore, G., Vito, F., Aldo C., Roberto, A., Marilisa, A., Giovanni, A., & Tommaso, F. (2005). Effects of High versus Low Positive End-Expiratory Pressures in Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine, 171, 1002–1008.

Rittayamai, N., Katsios, C. M., Brochard, L., Friedrich, J. O., Mancebo, J., & Brochard, L. (2015). Pressure-controlled vs volume-controlled ventilation in acute respiratory failure: a physiology-based narrative and systematic review. Chest Journal, 148(2), 340–355.

Chiumello, D., Brochard, L., Marini, J. J., Slutsky, A. S., Mancebo, J., Ranieri, V. M., … Vincent, J. L. (2017).Respiratory support in patients with acute respiratory distress syndrome: an expert opinion. Critical Care, 21(1), 240.

Sud, S., Sud, M., Friedrich, J. O., Wunsch, H., Meade, M. O., Ferguson, N. D., … Adhikari, N. K. (2016). High-frequency oscillatory ventilation versus conventional ventilation for acute respiratory distress syndrome. The Cochrane Database of Systematic Reviews, 4, CD004085.

Meade, M. O., Young, D., Hanna, S., Zhou, Q., Bachman, T. E., Bollen, C., … Ferguson, N. D. (2017). Severity of hypoxemia and effect of high frequency oscillatory ventilation in ARDS. American Journal of Respiratory and Critical Care Medicine, 727-733.

Mireles, C. E., & Kacmarek, R. M. (2016). Should Airway Pressure Release Ventilation Be the Primary Mode in ARDS? Respiratory Care, 61(6), 761-773.

Gonzalez, M., Arroliga, A. C., Frutos, V. F., Raymondos, K., Esteban, A., Putensen, C., … Ferguson, N. D. (2010). Airway pressure release ventilation versus assist-control ventilation: a comparative propensity score and international cohort study. Intensive Care Medicine, 36(5), 817-827.

Maung, A. A, & Kaplan, L. J. (2011). Airway pressure release ventilation in acute respiratory distress syndrome. Critical Care Clinics, 27(3), 501-509.

Mikkelsen, M. E., Christie, J. D., Lanken, P. N., Biester, R. C., Thompson, B. T., Bellamy, S. L., …, Angus, D. C. (2012). The adult respiratory distress syndrome cognitive outcomes study: long-term neuropsychological function in survivors of acute lung injury. American Journal of Respiratory and Critical Care Medicine, 185(12), 1307–1315.

Girardis, M., Busani, S., Damiani, E., Donati, A., Rinaldi, L., Marudi, A., …, Singer, M. (2016). Effect of conservative vs conventional oxygen therapy on mortality among patients in an intensive care unit: the Oxygen-ICU randomized clinical trial. The Journal of the American Medical Association, 316(15), 1583–1589.

Neil, R., Aggarwal, & Roy, G. B. (2014). Targeting Normoxemia in Acute Respiratory Distress Syndrome May Cause Worse Short-Term Outcomes because of Oxygen Toxicity. The Annals of the American Thoracic Society, 11(9), 1449–1453.

Brower, R. G., Matthay, M. A., Morris, A., Schoenfeld, D., Thompson, B. T., & Wheeler, A. (2000). Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The New England journal of medicine, 342(18), 1301–1308.

Curley, G., Hayes, M., & Laffey, J. G. (2011). Can permissive hypercapnia modulate the severity of sepsis-induced ALI/ARDS? Critical Care, 15(2), 212.

Mekontso, D. A., Charron, C., Devaquet, J., Aboab, J., Jardin, F., Brochard, L., & Vieillard-Baron, A. (2009). Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome. Intensive Care Medicine, 35(11), 1850–1858.

Kregenow, D. A., Rubenfeld, G. D., & Hudson, L. D. (2006). Hypercapnic acidosis and mortality in acute lung injury. Critical Care Medicine, 34(1), 1–7.

Nin, N., Muriel, A., Peñuelas, O., Brochard, L., Lorente, J. A., Ferguson N. D., …, Esteban, A. (2017). Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome. Intensive Care Medicine, 43(2), 200–208.

Peter, R., Salvatore, M. M., & Alain, M. (2017). FIFTY YEARS OF RESEARCH IN ARDS: Gas Exchange in Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med, 196(8), 964–984.

Alain, C., Antonio, P., & Marco, R. (2017). FIFTY YEARS OF RESEARCH IN ARDS: Is Extracorporeal Circulation the Future of Acute Respiratory Distress Syndrome Management? American Journal of Respiratory and Critical Care Medicine, 195(9), 1161–1170.

Fanelli, V., Ranieri, M. V., Mancebo, J., Moerer, O., Quintel, M., Morley, S., …, Combes, A. (2016). Feasibility and safety of lowflow extracorporeal carbon dioxide removal to facilitate ultraprotective ventilation in patients with moderate acute respiratory distress syndrome. Critical Care, 20, 36.

Guerin, C., Reignier, J., Richard, J. C., Beuret, P., Gacouin, A., Boulain, T., …, Ayzac, L. (2013). Prone positioning in severe acute respiratory distress syndrome. The New England journal of medicine, 368(23), 2159-2168.

Guervilly, C., Bisbal, M., Forel, J. M., Mechati, M., Lehingue, S., Bourenne, J., …, Papazian, L. (2017). Effects of neuromuscular blockers on transpulmonary pressures in moderate to severe acute respiratory distress syndrome. Intensive Care Medicine, 43(3), 408–418.

Papazian, L., Forel, J. M., Gacouin, A., Penot-Ragon, C., Perrin, G., Loundou, A. …, Roch, A. (2010). Neuromuscular blockers in early acute respiratory distress syndrome. The New England journal of medicine, 363(12), 1107–1116.

Prielipp, R. C., Coursin, D. B., & Scuderi, P. E. (1995). Comparison of the infusion requirements and recovery profiles of vecuronium and cisatracurium 51W89 in intensive care unit patients. Anesthesia and analgesia, 81(1), 3-12.

Sessler CN. (2013). Counterpoint: Should paralytic agents be routinely used in severe ARDS? No. Chest Journal, 144(5), 1442-1445.

Gebistorf, F., Karam, O., Wetterslev, J., & Afshari, A. (2016). Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults. The Cochrane Database of Systematic Reviews, 6, CD002787.

Peter, J. V., John, P., Graham, P. L., Moran, J. L., George, I. A., & Bersten, A. (2008). Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. British Medical Journal, 336, 1006–1009.

Steinberg, K. P., Hudson, L. D., & Goodman, R. B. (2006). Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. The New England journal of medicine, 354(16), 1671-1684.

Xiong, B., Wang, C., Tan, J., Cao, Y., Zou, Y., Yao, Y., …, Huang, J. (2016). Statins for the prevention and treatment of acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. Respirology, 21(6), 1026–1033.

Grissom, C. K., Hirshberg, E. L., Dickerson, J. B., Brown, S. M., Lanspa, M. J., Liu, K. D., …, Morris, A. H. (2015). Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome. Critical Care Medicine, 43(2), 288-295.

Rice, T. W., Wheeler, A. P., & Thompson, B. T. (2012). Initial Trophic vs Full Enteral Feeding in Patients With Acute Lung Injury: The EDEN Randomized Trial. The Journal of the American Medical Association, 307(8),795-803.

Raghavendran, K., Pryhuber, G. S., Chess P. R., Davidson, B. A., Knight, P. R., & Notter, R. H. (2008). Pharmacotherapy of Acute Lung Injury and Acute Respiratory Distress Syndrome. Current Medicinal Chemistry, 15(19), 1911–1924.